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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
Published on: May 10, 2021
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Aortic valve calcification predicts poor outcomes after primary percutaneous coronary intervention
Chunfeng Dai1,2,3, Muyin Liu1,2,3, You Zhou1,2,3
1Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
European Journal of Clinical Investigation
|June 24, 2022
Summary
Aortic valve calcification, identified by echocardiography, predicts long-term adverse cardiovascular events after primary PCI for heart attack. This finding aids risk stratification in patients undergoing PCI.
Area of Science:
- Cardiology
- Echocardiography
- Interventional Cardiology
Background:
- Aortic valve calcification (AVC) is linked to cardiovascular risk.
- Primary percutaneous coronary intervention (PCI) is a key treatment for acute myocardial infarction (AMI).
Purpose of the Study:
- To determine if AVC detected by echocardiography predicts long-term adverse events post-primary PCI in AMI patients.
- To assess AVC as a prognostic marker in this high-risk population.
Main Methods:
- A cohort study of 2117 patients undergoing primary PCI from 2009-2018.
- AVC assessed via transthoracic echocardiography 1-3 days post-PCI.
- Major adverse cardiovascular and cerebral events (MACCE) tracked during follow-up, with propensity score matching used for analysis.
Main Results:
- 26.7% of patients had AVC; they were older, more often female, and had more comorbidities.
- AVC was associated with a higher incidence of MACCE (42.9% vs. 29.4%).
- Propensity score matching confirmed AVC independently increased MACCE risk (aHR 1.442, p<0.001).
Conclusions:
- Echocardiography-identified AVC is an independent predictor of long-term MACCE after primary PCI in AMI patients.
- AVC serves as a valuable imaging biomarker for enhanced risk stratification in this patient group.
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