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Histologic and Immunohistochemical Evaluation of Radiosurgery in Strabismus Surgery in a Rabbit Model
Demet Yolcu1, Ahmet M Hondur2, Nalan Akyürek3
1Department of Ophthalmology, University of Health Sciences, Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.
Current Eye Research
|June 24, 2022
Summary
Monopolar radiosurgery (MRS) offers comparable hemostasis and wound healing to conventional strabismus surgery. This novel method enhances surgeon comfort by providing a cleaner surgical field during muscle incisions.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Histopathology
Background:
- Strabismus surgery traditionally involves muscle cutting techniques with varying degrees of tissue trauma and bleeding.
- Evaluating novel surgical methods like monopolar radiosurgery (MRS) is crucial for improving patient outcomes and surgical efficiency.
Purpose of the Study:
- To assess the efficacy of monopolar radiosurgery (MRS) in strabismus surgery.
- To compare the histologic and immunohistochemical wound healing outcomes of MRS with conventional surgical techniques.
Main Methods:
- Superior rectus muscle resection was performed on 30 rabbits using three techniques: MRS, conventional scissors with bipolar electrocautery (BEC), and conventional scissors alone (control).
- Evaluated parameters included tissue injury, bleeding, inflammation, fibrosis, and wound healing rate (CD68+ cell count).
Main Results:
- MRS group showed significantly lower hemorrhage scores compared to conventional scissors (CS) and bipolar electrocautery (BEC) groups.
- BEC group exhibited higher tissue injury scores than the MRS group (p=0.028).
- Fibrosis scores were significantly higher in the control group compared to the MRS group (p<0.011).
Conclusions:
- Monopolar radiosurgery (MRS) is a viable alternative for strabismus surgery, demonstrating effective hemostasis and comparable wound healing.
- MRS enhances surgeon comfort through single-step muscle incisions and a cleaner surgical field, without compromising tissue healing.
