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Efficient encapsulation of curcumin into spent brewer's yeast using a pH-driven method.

Dong-Wen Fu1, Jing-Jing Fu1, Jing-Jing Li1

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Summary

This study introduces a pH-driven method for encapsulating curcumin (CUR) into yeast cells (YCs), significantly improving loading capacity and reducing incubation time. The enhanced yeast cell encapsulation boosts curcumin

Keywords:
BioaccessibilityCurcuminEncapsulation efficiencySpent brewer's yeastpH-driven method

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Area of Science:

  • Biotechnology
  • Materials Science
  • Food Science

Background:

  • Curcumin (CUR) is a bioactive compound with limited bioavailability.
  • Yeast cells (YCs) offer potential as natural microcarriers for bioactive substances.
  • Efficient encapsulation methods are needed to improve CUR delivery and efficacy.

Purpose of the Study:

  • To develop and optimize a pH-driven method for encapsulating CUR into YCs.
  • To characterize the encapsulation process and the state of CUR within YCs.
  • To evaluate the in vitro bioaccessibility of CUR encapsulated in YCs.

Main Methods:

  • pH-driven encapsulation of CUR into YCs.
  • Optimization of CUR to YC mass ratio.
  • Characterization using fluorescence microscopy, DSC, TGA, FTIR, and XRD.
  • In vitro bioaccessibility assessment.

Main Results:

  • Achieved a 5.04-fold increase in loading capacity and 43.63-fold reduction in incubation time compared to conventional methods.
  • Optimal CUR:YC mass ratio of 0.1 yielded 8.07% loading capacity and 80.66% encapsulation efficiency.
  • Confirmed CUR interaction with YC cell wall components (mannoprotein, β-glucan) via hydrophobic and hydrogen bonding in an amorphous state.
  • Demonstrated a 6.05-fold increase in in vitro bioaccessibility of YC-loaded CUR.

Conclusions:

  • The pH-driven method provides an efficient and rapid approach for CUR encapsulation into YCs.
  • Encapsulated CUR exists in an amorphous state within the YC cell wall network.
  • YC-based microcarriers significantly enhance the in vitro bioaccessibility of CUR, offering a promising delivery system.