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Published on: October 30, 2010
APOE told me put my fat in the bag and nobody gets hurt
1Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Neurosciences Interdepartmental Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Abstract:
The ε4 variant in the APOE gene is the strongest genetic risk factor for Alzheimer's disease. How does this gene impact different cell types in the brain to increase disease risk? In this issue of Cell, TCW and colleagues report APOE-driven cell-type-specific changes that may contribute to Alzheimer's disease risk.
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