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Light-responsive biomaterials for ocular drug delivery
Hend A M Abdelmohsen1,2,3, Nikki A Copeland2,4, John G Hardy5,6
1Department of Chemistry, Lancaster University, Lancaster, LA1 4YB, Lancashire, UK.
Abstract:
Light-responsive biomaterials can be used for the delivery of therapeutic drugs and nucleic acids, where the tunable/precise delivery of payload highlights the potential of such biomaterials for treating a variety of conditions. The translucency of eyes and advances of laser technology in ophthalmology make light-responsive delivery of drugs feasible. Importantly, light can be applied in a non-invasive fashion; therefore, light-triggered drug delivery systems have great potential for clinical impact. This review will examine various types of light-responsive polymers and the chemistry that underpins their application as ophthalmic drug delivery systems.
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