Related Experiment Video
Updated: Sep 6, 2025
06:45
Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
2.9K
Differences in Brain Activity Between Dopa-Responsive and -Unresponsive Pain in Parkinson's Disease
Jin Hua Zheng1,2,3, Wen Hua Sun1,2, Jian Jun Ma4,5,6
1Department of Neurology, Henan Provincial People's Hospital, Weiwu Road, Building 7, Zhengzhou, 450003, Henan Province, People's Republic of China.
Pain and Therapy
|June 25, 2022
Summary
Parkinson's disease pain mechanisms differ. Dopa-unresponsive pain involves distinct brain activity and connectivity compared to dopa-responsive pain or no pain, suggesting varied therapeutic targets.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Pain in Parkinson's disease (PD) is complex and often unresponsive to standard dopaminergic treatments.
- Understanding the underlying neural mechanisms is crucial for developing effective pain management strategies in PD.
Purpose of the Study:
- To investigate the neural activity and functional connectivity differences in patients with dopa-responsive pain, dopa-unresponsive pain, and no pain.
- To elucidate distinct mechanisms contributing to different pain types in Parkinson's disease.
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) was employed.
- Neural activity (amplitude of low-frequency fluctuation) and functional connectivity were analyzed in 31 dopa-responsive pain, 51 dopa-unresponsive pain, and 93 no-pain PD patients.
Main Results:
- Dopa-unresponsive pain showed higher neural activity in the right parahippocampal/lingual region compared to no pain.
- Significant differences in functional connectivity were observed in dopa-unresponsive pain patients (e.g., superior temporal gyrus, amygdala, thalamus, putamen).
- Dopa-responsive pain patients exhibited distinct functional connectivity patterns (e.g., temporal fusiform cortex, cerebellum, precentral gyrus).
Conclusions:
- Regional brain activity and functional connectivity patterns are significantly different across PD pain phenotypes.
- Dopa-responsive and dopa-unresponsive pain likely originate from distinct pathophysiological mechanisms.
- These findings may inform the development of targeted pain therapies for Parkinson's disease.
Related Concept Videos
01:37Neural Regulation
39.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.8K
01:24Parkinson's Disease: Treatment
371
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
371
01:15Parkinson's Disease: Overview
700
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
700
01:25Analgesia and Pain Management
788
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
788