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Related Experiment Video

Updated: Sep 6, 2025

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METTL3 plays a crucial function in multiple biological processes.

Guilan Li1, Zhanbing Sun1, Weihua Deng1

  • 1Department of Preventive Medicine, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China; Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazardsa, Hengyang Medical School, University of South China, Hengyang, China.

Acta Histochemica
|June 25, 2022
PubMed
Summary
This summary is machine-generated.

N6-methyladenosine (m6A) is a key RNA modification. Methyltransferase-like 3 (METTL3) plays a crucial role in various diseases, offering potential therapeutic targets.

Keywords:
DiseaseMETTL3Methyltransferasem(6)A

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Area of Science:

  • Epigenetics
  • RNA biology
  • Molecular oncology

Background:

  • N6-methyladenosine (m6A) is a prevalent epitranscriptomic modification in eukaryotic RNA.
  • m6A modifications are dynamically regulated by methyltransferases and demethylases.
  • Advancements in m6A sequencing have elucidated its biological significance and mechanisms.

Purpose of the Study:

  • To review the multifaceted roles of Methyltransferase-like 3 (METTL3) in biological processes.
  • To explore METTL3's involvement in epithelial-mesenchymal transition (EMT), inflammation, and therapy resistance.
  • To highlight METTL3 as a potential diagnostic and therapeutic target for human diseases.

Main Methods:

  • Literature review focusing on m6A modification and METTL3.
  • Analysis of studies investigating METTL3's role in cellular functions and disease pathology.
  • Synthesis of current understanding regarding METTL3's molecular mechanisms.

Main Results:

  • METTL3 is a key m6A methyltransferase implicated in diverse biological functions.
  • METTL3 interacts with tumor cells and influences the development of various human diseases.
  • METTL3 impacts EMT, inflammatory responses, and sensitivity to chemo-radiotherapies.

Conclusions:

  • METTL3's regulatory functions are critical in biological processes and disease pathogenesis.
  • Understanding METTL3's molecular mechanisms provides insights into disease development.
  • METTL3 represents a promising target for novel therapeutic and diagnostic strategies in human diseases.