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In missed abortion the decrease of IGF-1 down-regulates PI3K/AKT signaling pathway reducing the secretion of

Weitao Liang1, Tianyuan Zhu2, Na Tan3

  • 1Institute of Maternal, Child and Adolescent Health, School of Public Health, Lanzhou University, Lanzhou 730000, China.

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
|June 25, 2022
PubMed
Summary

Reduced Insulin-like Growth Factor-1 (IGF-1) in missed abortion down-regulates the PI3K/AKT pathway, increasing trophoblast cell apoptosis and lowering key hormone levels.

Keywords:
IGF-1Missed abortionPI3K/AKT signaling pathwayProgesterone and β-hCGVillous trophoblast apoptosis

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