Similarity-based fMRI-MEG fusion reveals hierarchical organisation within the brain's semantic system

Our ability to understand and interact with our environment relies upon conceptual knowledge of the meaning of objects. This process is supported by a distributed network of frontal, parietal, and temporal brain regions. Insight into the differential roles of various elements of this system can be inferred from the timing of activation, and here we use similarity-based fMRI-MEG fusion to understand when the representational spaces in different elements of the semantic system converge with representational spaces in the evolving MEG signal. Participants performed a semantic-typicality judgement of written words drawn from nine different semantic categories in separate fMRI and MEG sessions. Results indicate an initial period of congruence between MEG and fMRI informational spaces dominated by the posterior inferior temporal gyrus and the ventral temporal cortex between 350 and 450 msec. This is followed by a second period of convergence between 450 and 795 msec where MEG and fMRI representational spaces conform in left angular gyrus and precuneus in addition to ventral temporal cortex. Results are consistent with the multistage recruitment of the semantic system, initially involving automatic aspects of the representational system and later extending to broader elements of the semantic system more strongly associated with internalised cognition.