Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurotransmitters01:31

Neurotransmitters

1.4K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
1.4K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

944
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
944
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

382
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
382
Cholinergic Neurons: Neurotransmission01:23

Cholinergic Neurons: Neurotransmission

3.5K
Cholinergic neurotransmission involves the synthesis and the release of acetylcholine (ACh) in order to transmit nerve impulses across the synapse. The process begins with the synthesis of acetyl CoA, a precursor for ACh, from ATP, acetate, and coenzyme A in the mitochondria. Choline, another vital precursor, is transported inside the neuron through choline transporters, including high-affinity choline transporter CHT1, low-affinity choline transporter CTL1, and lower-affinity choline...
3.5K
Indirect-Acting Cholinergic Agonists: Mechanism of Action01:18

Indirect-Acting Cholinergic Agonists: Mechanism of Action

2.0K
Indirect-acting cholinergic agonists work by interacting with an enzyme called acetylcholinesterase (AChE) in the synaptic cleft. They can be reversible or irreversible inhibitors and have different effects on the enzyme.
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex,...
2.0K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

511
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
511

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Biofilm-forming ability of Staphylococcus aureus on materials commonly found in milking equipment surfaces.

Journal of dairy science·2025
Same author

Fracture Resistance and Failure Mode of Polyethylene Fiber-reinforced Resin-based Restorations in Structurally Compromised Premolars: an in Vitro Study.

Operative dentistry·2024
Same author

Observation of Interatomic Coulombic Decay Induced by Double Excitation of Helium in Nanodroplets.

Physical review letters·2024
Same author

Clinical presentations and outcomes of HIV-1 and HIV-2 among infected children in Guinea-Bissau: a nationwide study.

Public health·2024
Same author

Biocidal effects of organometallic materials supported on ZSM-5 Zeolite: Influence of the physicochemical and surface properties.

Heliyon·2024

Related Experiment Video

Updated: Sep 6, 2025

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

2.5K

Oxytocin-Cholinergic Central Interaction: Implications for Non-Social Memory Formation.

C Medina1, M C Krawczyk1, J Millan1

  • 1Laboratorio de Neurofarmacología de los Procesos de Memoria, Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.

Neuroscience
|June 25, 2022
PubMed
Summary

Central administration of oxytocin (OT) impairs memory, while its antagonist enhances it. This effect is mediated by the cholinergic system, crucial for memory formation.

Keywords:
acetylcholineinhibitory avoidancelinopirdinemiceneuropeptide

More Related Videos

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
09:12

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

8.0K
Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

27.2K

Related Experiment Videos

Last Updated: Sep 6, 2025

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

2.5K
Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
09:12

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

8.0K
Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

27.2K

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology

Background:

  • Oxytocin (OT) and vasopressin (AVP) are neuropeptides involved in various cognitive and behavioral processes.
  • Previous studies indicated peripheral OT impairs, while AVP enhances learning and memory.

Purpose of the Study:

  • To investigate the central effects of OT and its antagonist (AOT) on memory formation.
  • To explore the interaction between central OT and the cholinergic system in memory processes.

Main Methods:

  • Intracerebroventricular (ICV) administration of OT and AOT in mice.
  • Evaluation of inhibitory avoidance response 48 hours post-training.
  • Administration of anticholinesterase inhibitors, muscarinic/nicotinic agonists, and antagonists.

Main Results:

  • Central OT administration dose-dependently impaired inhibitory avoidance memory.
  • Central AOT administration dose-dependently enhanced memory performance.
  • Cholinergic system activation reversed OT-induced memory impairment.
  • Cholinergic antagonists reduced the memory-enhancing effect of AOT.

Conclusions:

  • Central OT impairs memory formation by potentially inducing a cholinergic hypofunction state.
  • The cholinergic system is essential for the memory effects of OT and its antagonist.