A model of minimal entropy generation for cytoskeletal transport systems with multiple interacting motors

We study the steady-state rate of entropy generation for multiple interacting particles. The description used is based on the partially asymmetric exclusion process in a lattice with periodic boundary conditions. Our methodology shows that in the steady-state, the rate of entropy generation is directly proportional to the bulk drift and the applied driving force. Since in many cases the driving force is unknown or hard to determine. We circumvent this by deriving a lower bound for the entropy, resulting in an extended thermodynamic uncertainty relation for the asymmetric simple exclusion process. We systematically compared this bound with the actual entropy generation. Thus, we identify the force regimes, and particles' density conditions where the entropy bound derived from this extended thermodynamic uncertainty relation is meaningful.