Related Experiment Video

Updated: Sep 6, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.0K

NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and

Shirin Kahremany1, Lukas Hofmann2, Arie Gruzman2

  • 1Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat-Gan, 5290002, Israel; The Skin Research Institute, The Dead Sea and Arava Science Center, Masada, 86910, Israel.

Free Radical Biology & Medicine
|June 26, 2022
PubMed

Insights

Activating the NRF2 pathway offers comprehensive protection against skin damage from ultraviolet radiation (UVR). This approach shows promise for treating photodermatosis and preventing photocarcinogenesis.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Biochemistry

Background:

  • The skin barrier is constantly challenged by environmental stressors, notably ultraviolet radiation (UVR).
  • While the skin possesses protective mechanisms, comprehensive strategies are needed to mitigate UVR-induced damage, especially for photocarcinogenesis and photodermatosis.
  • The NRF2 pathway's activation is a promising avenue for enhancing cellular defense against UVR.

Purpose of the Study:

  • To review the detrimental effects of UVR on normal skin and in photodermatosis.
  • To explore the potential of NRF2 activators as a pharmacological strategy for photoprotection.
  • To summarize existing natural and synthetic NRF2 activators with photoprotective capabilities.

Main Methods:

  • Literature review of UVR-induced skin alterations.
  • Analysis of NRF2 pathway's role in cellular protection.
  • Compilation of data on NRF2 activators and their photoprotective properties.

Main Results:

  • UVR causes significant damage to skin cells, which is exacerbated in photodermatosis.
  • NRF2 activation upregulates cytoprotective proteins, counteracting UVR-induced damage effectively.
  • Several natural and synthetic compounds demonstrate potential as NRF2-activating photoprotective agents.

Conclusions:

  • NRF2 activation presents a robust strategy for broad and sustained photoprotection.
  • Developing NRF2 activators could offer novel therapeutic options for photodermatosis and prevention of UVR-related skin damage.
  • Further research is needed to address knowledge gaps concerning NRF2 activation in photodermatosis.
Keywords:
NRF2Pharmacological interventionPhotocarcinogensPhotodamagePhotodermatosisSulforaphaneUVAUVBUltraviolet

More Related Videos

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.3K
In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model06:40

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model

Published on: November 17, 2018

11.1K

Related Concept Videos

Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.8K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.8K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.6K
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.6K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.1K