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Related Experiment Video

Updated: Sep 6, 2025

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Mapping frontoinsular cortex from diffusion microstructure.

Ryan P Cabeen¹, Arthur W Toga¹, John M Allman²

¹Laboratory of Neuro Imaging, USC Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA 90033, United States.

Cerebral Cortex (New York, N.Y. : 1991)

|June 26, 2022

Summary

This summary is machine-generated.

We developed a novel MRI method to map the frontoinsular cortex (FI). Larger FI volume in individuals correlates with better self-control and social awareness.

Keywords:

anterior agranular insular cortex decision-making diffusion MRI frontoinsular cortex social behavior

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Area of Science:

Neuroimaging
Neuroanatomy
Cognitive Neuroscience

Background:

The frontoinsular cortex (FI) is crucial for affective processing and linked to neurodegenerative diseases.
Structural neuroimaging of FI has been limited despite its importance.
FI contains unique von Economo neurons (VENs) implicated in various conditions.

Purpose of the Study:

To develop a novel method for mapping FI using structural and diffusion MRI.
To investigate the relationship between FI structure and behavioral factors.
To quantify FI volume differences across hemispheres and sexes.

Main Methods:

Developed a novel method combining cortical surface geometry and diffusion microstructure parameters to delineate FI.
Utilized structural and diffusion magnetic resonance imaging (MRI).
Analyzed data from 1052 young adults in the Human Connectome Project.

Main Results:

Neurite orientation dispersion in gray matter effectively maps FI.
FI volume is larger in the left hemisphere (31%) and in women (15.3%).
FI volume correlates with decision-making, emotion regulation, and social cognition.

Conclusions:

The novel MRI technique enables precise FI mapping.
FI volume is sexually dimorphic and lateralized.
Larger FI volume is associated with enhanced self-control and social awareness.