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Updated: Sep 6, 2025
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Association of coronary artery calcification with SYNTAX scores and GRACE
Insights
Coronary artery calcification score (CACS) and calcified vessel count effectively predict coronary atherosclerotic heart disease (CHD) severity and future cardiovascular event risk. These measures aid in treatment planning before angiography.
Area of Science:
- Cardiology
- Radiology
- Preventive Medicine
Background:
- Coronary atherosclerotic heart disease (CHD) poses a significant global health burden.
- Accurate risk stratification and prediction of disease severity are crucial for effective patient management.
- Non-invasive imaging markers like coronary artery calcification score (CACS) are increasingly utilized.
Purpose of the Study:
- To explore the correlations between CACS, number of calcified vessels, SYNTAX score, and GRACE score in CHD patients.
- To assess the predictive and diagnostic values of CACS and calcified vessel count for CHD severity and risk stratification.
Main Methods:
- Retrospective analysis of 214 CHD patients' data, including CACS, calcified vessel count, SYNTAX score, and GRACE score.
- Statistical analyses included Spearman correlation, binary logistic regression, and Receiver Operator Characteristic (ROC) curve analysis.
- Patients were grouped by CACS and calcified vessel number to compare SYNTAX and GRACE scores.
Main Results:
- CACS and calcified vessel number showed positive correlations with SYNTAX score (r=0.505, P<0.01; r=0.533, P<0.01, respectively).
- CACS correlated with GRACE score (r=0.195, P<0.01), while calcified vessel number did not (r=-0.14, P=0.899).
- ROC analysis indicated good diagnostic value for CACS and calcified vessel number in predicting CHD and high-risk SYNTAX score groups.
Conclusions:
- CACS and calcified vessel number are valuable predictors of CHD severity and future cardiovascular event risk.
- Pre-angiography assessment of CACS and calcified vessel count offers clinical utility in predicting coronary lesion severity and guiding treatment strategies.
Objectives:
To investigate the relationship among coronary artery calcification score (CACS), the number of calcification vessels, SYNTAX score and GRACE score in patients with coronary atherosclerotic heart disease (CHD).
Methods:
The CACS, calcification vessel number, SYNTAX score, and GRACE score were collected or calculated from 214 CHD patients admitted in Haikou People's Hospital from January 2014 to April 2019. Patients were assigned into several groups according to the CACS and calcification vessel number, and then to compare the differences in SYNTAX and GRACE scores between groups. Spearman correlation coefficient was used to analyze the correlation between CACS or calcification vessel number and SYTAX score or GRACE score. Regression of binary logistic was used to analyze independent risk factors for coronary calcification. The diagnostic values of the CACS and calcification vessel number for predicting CHD, and SYNTAX score and GRACE score high-risk group were evaluated by the receiver operator characteristic (ROC) curve.
Results:
Spearman correlation analysis showed that CACS was positively correlated with SYTAX score (r=0.505, P<0.01) or GRACE score (r=0.195, P<0.01). The number of calcified vessels was positively correlated with the SYNTAX score (r=0.533, P<0.01), but not with the GRACE score (r=-0.14, P=0.899). Regression of binary logistic showed that male and SYTAX scores were independent risk factors for coronary artery calcification (P<0.05). The analysis of ROC curve showed that the CACS was of good value in the diagnosis of CHD (AUC=0.756, P<0.01) and SYNTAX score high-risk group (AUC=0.781, P<0.01), while it was of lower value in the diagnostic of the GRACE score high-risk group (AUC=0.698, P<0.01). The value of calcification vessel number in the diagnosis of CHD (AUC=0.763, P<0.01) and the SYNTAX score high-risk group (AUC=0.868, P<0.01) was good, but that in the diagnosis of the GRACE score high-risk group (AUC=0.601, P=0.07) was not statistically significant.
Conclusions:
In patients with suspected CHD, CACS and calcification vessel number can predict the severity of CHD and the risk of future cardiovascular events. Measuring the CACS and the number of calcification vessels before coronary angiography has certain clinical significance for predicting the severity of coronary lesion and formulating the treatment plan.
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