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Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
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A Stratified Analysis of the Risk Associated With Low Body Mass Index for Patients After Percutaneous Coronary

Takeo Horikoshi1, Takamitsu Nakamura1, Toru Yoshizaki1

  • 1Department of Cardiology, University of Yamanashi, Faculty of Medicine.

Journal of Atherosclerosis and Thrombosis
|June 26, 2022
PubMed

Insights

Low body mass index (BMI) increases risks for patients undergoing percutaneous coronary intervention (PCI). This risk is heightened in men, older adults, and those with diabetes or acute coronary syndrome.

Area of Science:

  • Cardiology
  • Public Health

Background:

  • Low body mass index (BMI) is prevalent in elderly Japanese patients with coronary artery disease (CAD).
  • Limited research exists on the prognosis of patients with low BMI following percutaneous coronary intervention (PCI).

Purpose of the Study:

  • To analyze the association between low BMI and adverse outcomes in patients after PCI.
  • To identify specific risk factors that exacerbate the impact of low BMI on patient prognosis.

Main Methods:

  • A prospective, multicenter registry of 5965 patients with CAD who underwent successful PCI.
  • Clinical follow-up for up to 3 years, monitoring major adverse cardiac events.
  • Multivariable-adjusted models to assess the risk associated with low BMI and other factors.

Main Results:

  • Underweight patients had a significantly increased risk of all-cause death or nonfatal myocardial infarction (HR 1.43).
  • Risk was elevated in elderly individuals, those with diabetes mellitus (DM), peripheral artery disease, low ejection fraction, acute coronary syndrome (ACS), and smokers.
  • The increased risk for underweight patients was more pronounced in men, those aged 60-74, and patients with DM or ACS.

Conclusions:

  • Underweight status is an independent risk factor for adverse outcomes after PCI, particularly when combined with other risk factors.
  • Specific subgroups, including men, middle-aged adults (60-74 years), and patients with DM or ACS, face a more significant risk associated with low BMI.
Abstract

Keywords:
MortalityNutrition/obesityPercutaneous coronary interventionRisk assessment

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