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Alterations in brain catecholamines during pregnancy.

A Smolen, T N Smolen, J L van de Kamp

    Pharmacology, Biochemistry, and Behavior
    |March 1, 1987
    PubMed
    Summary
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    Pregnant mice exhibit increased seizure susceptibility, linked to altered norepinephrine (NE) levels in the brain, particularly the hippocampus. Dopamine (DA) levels and turnover remained largely unchanged, suggesting NE plays a key role in this pregnancy-related neurological change.

    Area of Science:

    • Neuroscience
    • Neurochemistry
    • Reproductive Biology

    Background:

    • Pregnancy is associated with heightened susceptibility to seizures.
    • The neurochemical underpinnings of this phenomenon are not fully understood.
    • Catecholamines, including norepinephrine and dopamine, are implicated in seizure modulation.

    Purpose of the Study:

    • To investigate the role of brain catecholamines in enhanced seizure susceptibility during pregnancy.
    • To measure norepinephrine (NE) and dopamine (DA) concentrations and turnover rates in specific brain regions of pregnant and non-pregnant mice.

    Main Methods:

    • Concentration and turnover of NE and DA were measured in hippocampus, striatum, midbrain, and cortex.
    • Comparisons were made between control, pregnant, and delivery-day mice.

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  • Flurothyl-induced seizures were used as the behavioral model.

    • Main Results:

    • Dopamine levels showed no significant changes during pregnancy or parturition.
    • Norepinephrine concentration decreased during pregnancy, most notably in the hippocampus.
    • Norepinephrine turnover was significantly depressed during pregnancy, with the hippocampus being most affected.

    Conclusions:

    • Norepinephrine, but not dopamine, appears to mediate the increased seizure susceptibility observed during pregnancy.
    • The hippocampus is a key brain region affected by these neurochemical changes.
    • Findings suggest a specific role for NE in pregnancy-related neurological alterations.