Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regression Toward the Mean01:52

Regression Toward the Mean

6.5K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.5K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

171
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
171
Statistical Significance01:50

Statistical Significance

20.4K
Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
20.4K
Chi-square Analysis02:46

Chi-square Analysis

38.7K
The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
38.7K
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

633
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
633
One-Way ANOVA: Equal Sample Sizes01:15

One-Way ANOVA: Equal Sample Sizes

3.4K
One-Way ANOVA can be performed on three or more samples with equal or unequal sample sizes. When one-way ANOVA is performed on two datasets with samples of equal sizes, it can be easily observed that the computed F statistic is highly sensitive to the sample mean.
Different sample means can result in different values for the variance estimate: variance between samples. This is because the variance between samples is calculated as the product of the sample size and the variance between the...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic literature reviews in trauma research: what is important to know?

Injury·2026
Same author

Operative Treatment of an Isolated, Comminuted, Biarticular Trapezium Fracture: A Case Report and Review of the Literature.

Journal of wrist surgery·2025
Same author

Acetabular fractures in the elderly. what is the current evidence for optimal treatment?

Injury·2024
Same author

Distraction osteogenesis versus induced membrane technique for infected tibial non-unions with segmental bone loss: a systematic review of the literature and meta-analysis of available studies.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2023
Same author

Reconstruction of infected long bone defects: Issues and Challenges.

Injury·2023
Same author

Subtrochanteric femoral fractures and intramedullary nailing complications: a comparison of two implants.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology·2022

Related Experiment Video

Updated: Sep 6, 2025

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

72.9K

Meta-analysis. What have we learned?

Costas Papakostidis1, Peter V Giannoudis2

  • 1Consultant Orthopaedic and Trauma Surgeon. Assistant Director, Orthopaedic Department, Limassol General Hospital, Cyprus.

Injury
|June 26, 2022
PubMed
Summary

Meta-analyses in Evidence-Based Medicine (EBM) pool trial data for precise estimates. This review explores their methodology, benefits, and drawbacks in Orthopaedics and Trauma Surgery.

Keywords:
Evidence-based medicineMeta-analysisSystematic review

More Related Videos

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.2K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

691

Related Experiment Videos

Last Updated: Sep 6, 2025

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

72.9K
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.2K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

691

Area of Science:

  • Medical research methodology
  • Evidence-Based Medicine (EBM)
  • Biostatistics

Background:

  • Meta-analyses are crucial for synthesizing trial data in Evidence-Based Medicine (EBM).
  • They increase statistical power and precision by pooling outcome data from multiple studies.
  • Meta-analyses are considered the highest level of evidence for clinical practice guidelines.

Purpose of the Study:

  • To provide an overview of meta-analytic methodology.
  • To discuss the benefits and potential drawbacks of meta-analyses.
  • To address concerns regarding the timeliness and validity of meta-analyses in Orthopaedics and Trauma Surgery.

Main Methods:

  • Review of meta-analytic methodology.
  • Discussion of benefits including increased sample size and statistical power.
  • Examination of potential drawbacks such as complexity and time consumption.

Main Results:

  • Meta-analyses enhance the precision of effect estimates by combining data from individual studies.
  • The quality of included studies and the rigor of the meta-analytic process are critical.
  • Concerns exist regarding the efficiency of meta-analyses for generating timely evidence in specialized fields.

Conclusions:

  • Meta-analyses are powerful tools for evidence synthesis in EBM.
  • Their utility is contingent upon study quality and methodological rigor.
  • Careful consideration of benefits versus drawbacks is necessary, particularly in time-sensitive surgical fields.