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Non-Modifiable Factors as Moderators of the Relationship Between Physical Activity and Brain Volume: A
Belinda M Brown1,2,3, Jaisalmer de Frutos Lucas3,4, Tenielle Porter3,5,6
1Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia.
Journal of Alzheimer'S Disease : JAD
|June 27, 2022
Summary
Physical activity is linked to greater brain volume, particularly in males. Age also influences this relationship, suggesting personalized approaches to exercise for brain health.
Area of Science:
- Neuroscience
- Gerontology
- Exercise Physiology
Background:
- Physical activity may protect against brain matter loss.
- Individual responses to physical activity's brain benefits vary.
- Identifying influencing factors can predict personalized responses.
Purpose of the Study:
- Examine physical activity's link to brain volume.
- Investigate moderation by age, sex, and genetics (BDNF, APOE).
Main Methods:
- Utilized UK Biobank data from 10,083 adults (50+).
- Assessed brain volumes via MRI.
- Measured physical activity using actigraphy.
- Performed genotyping for candidate genes.
Main Results:
- Physical activity correlated with total grey matter, white matter, and right hippocampal volume.
- Males showed stronger associations between physical activity and grey matter volumes.
- Age moderated the physical activity-white matter volume relationship.
Conclusions:
- Physical activity is associated with grey matter volume in males, but not females.
- Age influences the relationship between physical activity and brain volume.
- Longitudinal studies are needed to clarify age and sex effects.
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