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A Protocol for Computer-Based Protein Structure and Function Prediction
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A Protocol for Computer-Based Protein Structure and Function Prediction

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Protein structure prediction improves the quality of amino-acid sequence alignment

Arthur M Lesk1, Arun S Konagurthu2

  • 1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, USA.

Proteins
|June 27, 2022
PubMed
Summary

Structural alignments improve protein evolution analysis. AlphaFold2 can generate accurate structural alignments from sequences alone, even for highly diverged proteins, enhancing homology detection.

Keywords:
AlphaFold2CASP14amino-acid sequence alignmentprotein structure prediction

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