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Planning system for the optimization of electric field delivery using implanted electrodes for brain tumor control
Erin Iredale1, Brynn Voigt2, Adam Rankin3
1Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Medical Physics
|June 27, 2022
Summary
This study developed a new treatment planning system for intratumoral modulation therapy (IMT) to control tumor growth using electric fields. The system was successfully validated on a brain phantom, advancing IMT for clinical trials.
Area of Science:
- Oncology
- Biomedical Engineering
- Medical Physics
Background:
- Intratumoral modulation therapy (IMT) utilizes low-intensity electric fields to control malignant tumor growth.
- IMT involves multiple implanted electrodes delivering electric fields within or adjacent to tumors.
- This approach shows promise as a novel cancer treatment modality.
Purpose of the Study:
- To advance the intratumoral modulation therapy (IMT) optimization algorithm.
- To develop a custom treatment planning system for patient-specific IMT.
- To demonstrate the system's practicality through a full optimization pipeline on a brain phantom.
Main Methods:
- Developed an integrated planning pipeline in 3D Slicer using patient MRI/CT scans.
- Implemented semi-automatic segmentation, manual electrode trajectory planning, and parameter optimization.
- Utilized robotic implantation software and validated with phantom imaging and stimulation.
Main Results:
- Created a unified, semi-automated IMT treatment planning system within 3D Slicer.
- Successfully validated the system on a brain phantom, including robotic implantation and stimulation adjustments.
- Measured voltage in the phantom to validate simulated electric field distribution.
Conclusions:
- A custom treatment planning and implantation system for IMT was developed and validated.
- This system represents a significant step towards clinical investigation of IMT.
- Further research will focus on clinical safety and efficacy of intratumoral modulation therapy.
