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Updated: Sep 6, 2025

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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Tumour-reactive B cells and antibody responses after allogeneic haematopoietic cell transplantation

G de Jong1,2,3, M A Gillissen1,3, H Spits4

  • 1Department of Haematology, Amsterdam UMC, Amsterdam, The Netherlands.

Immuno-Oncology Technology
|June 27, 2022
PubMed

For many high-risk haematologic malignancies, such as acute myeloid leukaemia, the success of therapy relies mainly on invoking a curative antitumour immune response. This can be achieved by inducing a graft-versus-leukaemia response following allogeneic haematopoietic cell transplantation. While the contribution of T cells and natural killer cells to graft-versus-leukaemia responses is established, the contribution of B cells and antibodies is relatively unexplored. This article reviews what is known about the contribution of B cells and tumour-specific antibody responses to a successful graft-versus-leukaemia response leading to eradication of the tumour.

Keywords:
B lymphocytesallogeneic hematopoietic stem cell transplantationgraft versus leukemia responseimmunotherapytumor specific antibodies

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