Related Experiment Video

Updated: Sep 6, 2025

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

10.5K

IgG4-related cardiovascular disease: imaging features on cardiac computed tomography and magnetic resonance imaging

S H Chandrashekhara1, Vineeta Ojha1, Pramod Kumar1

  • 1Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, Room no 10A, New Delhi, 110029 India.

Indian Journal of Thoracic and Cardiovascular Surgery
|June 27, 2022
PubMed

Insights

Immunoglobulin G4 (IgG4) vasculitis can affect the entire cardiovascular system. Computed tomography (CT) angiography is crucial for diagnosing this condition.

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Immunology

Background:

  • Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect various organs.
  • Cardiovascular involvement in IgG4-RD is increasingly recognized but often presents insidiously.
  • Vasculitis is a rare but serious manifestation of IgG4-RD.

Purpose of the Study:

  • To report a case of extensive cardiovascular involvement in a patient diagnosed with IgG4 vasculitis.
  • To emphasize the diagnostic utility of computed tomography (CT) angiography in identifying IgG4 vasculitis affecting cardiovascular structures.

Main Methods:

  • Case report presentation.
  • Detailed clinical, laboratory, and imaging findings.
  • Review of relevant literature.

Main Results:

  • The patient presented with diffuse involvement of multiple cardiovascular structures, including the aorta, coronary arteries, and cardiac chambers.
  • Computed tomography (CT) angiography revealed characteristic findings consistent with IgG4 vasculitis, aiding in diagnosis.
  • Histopathological examination confirmed the diagnosis and demonstrated IgG4-positive plasma cell infiltration.

Conclusions:

  • IgG4 vasculitis can lead to widespread cardiovascular compromise.
  • CT angiography is an invaluable tool for the early and accurate diagnosis of IgG4 vasculitis affecting the cardiovascular system.
  • Prompt diagnosis and treatment are essential to prevent severe cardiovascular complications.

Keywords:
Computed tomographyIgG4-related cardiovascular diseaseMagnetic resonance imaging

More Related Videos

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.7K
Cardiac Magnetic Resonance Imaging at 7 Tesla09:14

Cardiac Magnetic Resonance Imaging at 7 Tesla

Published on: January 6, 2019

11.6K

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
134
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
65
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
297
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
114
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
6.6K
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
50