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Updated: Sep 6, 2025
Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
Published on: December 20, 2024
The impact of splenectomy on human lipid metabolism
Orgun Gunes1, Emre Turgut2, Yusuf Murat Bag3
1Department of Gastrointestinal Surgery, Atatürk Training and Research Hospital, Izmir, Turkey.
Background:
Splenectomy impacts hematological, immunological, and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, is limited, this study aims to investigate the effects of splenectomy on lipid metabolism.
Methods:
The data from 316 patients undergoing splenectomy between 2009 and 2019 were retrospectively analyzed. Thirty-eight patients whose serum lipid values were measured both preoperatively and 1 year after surgery were included in this study.
Results:
Significantly higher levels of total cholesterol, low-density lipoprotein (LDL), and non-high-density lipoprotein (HDL) lipid profile were found in the postsplenectomy measurements. However, no significant differences were recorded in levels of triglyceride, HDL, or very-LDL.
Conclusion:
We determined that splenectomy does impact lipid metabolism, and that the metabolic effects of splenectomy should further be investigated.
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