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Radiomics-Guided Precision Medicine Approaches for Colorectal Cancer
1Department of Radiology, University of Tennessee Medical Center, Knoxville, TN, United States.
Abstract:
The concept of precision oncology entails molecular profiling of tumors to guide therapeutic interventions. Genomic testing through next-generation sequencing (NGS) molecular analysis provides the basis of such highly targeted therapeutics in oncology. As radiomic analysis delivers an array of structural and functional imaging-based biomarkers that depict these molecular mechanisms and correlate with key genetic alterations related to cancers. There is an opportunity to synergize these two big-data approaches to determine the molecular guidance for precision therapeutics. Colorectal cancer is one such disease whose therapeutic management is being guided by genetic and genomic analyses. We review the rationale and utility of radiomics as a combinative strategy for these approaches in the management of colorectal cancer.
Insights
Precision oncology uses genomic testing and radiomic analysis to guide cancer treatments. Combining these approaches can enhance precision therapeutics for colorectal cancer management.
Area of Science:
- Oncology
- Radiology
- Genomics
Background:
- Precision oncology relies on molecular tumor profiling for targeted therapies.
- Next-generation sequencing (NGS) provides genomic data for personalized cancer treatment.
- Radiomics offers imaging-based biomarkers reflecting molecular mechanisms and genetic alterations.
Purpose of the Study:
- To explore the synergy between radiomics and genomic analysis in oncology.
- To review the rationale and utility of combining radiomics with genomic data for precision therapeutics in colorectal cancer.
Main Methods:
- Review of current literature on precision oncology, NGS, and radiomics.
- Analysis of the potential for integrating radiomic biomarkers with genomic data.
- Focus on the application of this combined strategy in colorectal cancer management.
Main Results:
- Genomic testing and radiomics are powerful big-data approaches in cancer research.
- Radiomic features can correlate with specific genetic alterations in tumors.
- Synergizing these methods offers a promising avenue for guiding precision therapeutics.
Conclusions:
- Combining radiomics and genomic analysis can enhance the molecular guidance for precision oncology.
- This integrated approach holds significant potential for improving colorectal cancer management.
- Further research is warranted to fully leverage the combined power of radiomics and genomics.
