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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

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Updated: Sep 6, 2025

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma

Published on: November 15, 2024

Sprayable gel for postsurgical immunotherapy.

Qian Chen^1,2,3, Tianyuan Ci^2,3, Zhen Gu^2,3,4,5

¹Institute of Functional Nano and Soft Materials, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Jiangsu, PR China.

Immuno-Oncology Technology

|June 27, 2022

Summary

This summary is machine-generated.

A novel gel delivers anti-CD47 nanoparticles to surgical sites, activating immune responses to eliminate residual cancer cells and prevent tumor recurrence after surgery.

Keywords:

Cancer immunotherapy Local treatment Surgery Tumor recurrence

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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

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Published on: August 30, 2014

Area of Science:

Biomedical Engineering
Nanotechnology
Immunotherapy

Background:

Surgery is the primary treatment for solid tumors, but tumor recurrence remains a significant clinical challenge.
Effective strategies are needed to eliminate residual cancer cells post-surgery and prevent disease relapse.

Purpose of the Study:

To develop and evaluate an in-situ-sprayed gel for local delivery of immunotherapeutic nanoparticles after tumor resection.
To investigate the potential of this approach to reduce tumor recurrence by activating anti-tumor immune responses.

Main Methods:

An injectable gel was formulated with bioresponsive calcium carbonate nanoparticles (CaCO3) encapsulated with anti-CD47 antibodies (aCD47@CaCO3).
The gel was applied directly to the surgical site post-excision in a preclinical model.
The immunotherapeutic effects and anti-tumor efficacy of the localized treatment were assessed.

Main Results:

The CaCO3 nanoparticles reacted with the acidic tumor microenvironment, creating an immunosupportive milieu.
Released anti-CD47 antibodies blocked the 'don't eat me' signal on cancer cells, enhancing macrophage phagocytosis.
The treatment activated both innate and adaptive immune responses, leading to systemic anti-tumor immunity.

Conclusions:

The engineered immunotherapeutic gel effectively targets residual cancer cells at the surgical site.
This localized delivery system demonstrates significant potential in reducing tumor recurrence and improving patient outcomes.