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A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM

Riana Wurzburger1

  • 1Department of Internal Medicine, University of New Mexico Hospital, UNM School of Medicine MSC08 47201, University of New Mexico, Albuquerque, NM 87131, USA.

Case Reports in Hepatology
|June 27, 2022
PubMed

Insights

Teriflunomide, a multiple sclerosis drug, can cause rare liver injury. This case highlights probable drug-induced liver injury, which improved after stopping teriflunomide and using cholestyramine.

Area of Science:

  • Pharmacology
  • Hepatology
  • Neurology

Background:

  • Teriflunomide is a pyrimidine synthesis inhibitor.
  • It is used to treat multiple sclerosis (MS).
  • Rare instances of liver toxicity have been associated with teriflunomide.

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