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Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer
Shawn Ying Xuan Tan1, Jieqiong Zhang1,2, Wee-Wei Tee1,2,3
1Chromatin Dynamics and Disease Epigenetics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Frontiers in Cell and Developmental Biology
|June 27, 2022
Summary
Epigenetics, reversible genome changes, influence cell development and cancer. This review explores how epigenetics and inflammation interact, particularly in inflammation-induced cancer.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Research
Background:
- Epigenetics involves dynamic, reversible genome modifications without altering DNA sequence.
- Environmental and cellular microenvironments influence epigenetic processes crucial for development.
- Epigenetic dysregulation and chronic inflammation are key drivers of carcinogenesis.
Purpose of the Study:
- To review the intricate crosstalk between epigenetics and inflammation.
- To elucidate how epigenetic mechanisms control inflammatory gene transcription.
- To examine epigenomic profile changes in inflammation-induced cancer.
Main Methods:
- Literature review of epigenetic mechanisms.
- Analysis of inflammatory signaling pathways.
- Discussion of chromatin modulation in the tumor microenvironment.
Main Results:
- Epigenetic modifications regulate inflammatory gene expression.
- Inflammatory signaling impacts the global epigenetic landscape.
- Feedback loops exist between chromatin and inflammatory pathways.
Conclusions:
- Epigenetics and inflammation are deeply interconnected, especially in cancer.
- Understanding this crosstalk is vital for targeting inflammation-driven cancers.
- Epigenetic control of inflammation is a critical area for cancer research.
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