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Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia01:29

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Schizophrenia and Inflammation Research: A Bibliometric Analysis.

He-Li Sun1,2,3, Wei Bai1,2,3, Xiao-Hong Li4

  • 1Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao, Macao SAR, China.

Frontiers in Immunology
|June 27, 2022
PubMed
Summary

This bibliometric analysis maps 30 years of research on schizophrenia and inflammation. It identifies key countries, journals, and keywords, revealing the fundamental knowledge structure in this field.

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VOSviewerbibliometricshotspotsinflammationschizophrenia

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Area of Science:

  • Psychiatry and Neuroscience
  • Immunology

Background:

  • Schizophrenia (SCZ) is a severe psychiatric disorder linked to inflammatory processes.
  • Understanding the intersection of SCZ and inflammation is crucial for advancing psychiatric research.

Purpose of the Study:

  • To conduct a bibliometric analysis of inflammation-related research in schizophrenia.
  • To map the knowledge structure, collaboration networks, and emerging trends in SCZ and inflammation research.

Main Methods:

  • Bibliometric analysis of 3,596 publications from Web of Science Core Collection (inception to Feb 2022).
  • Utilized R package 'bibliometrix' and VOSviewer for data analysis, visualization, and keyword co-occurrence.
  • Employed CiteSpace for identifying top references and keywords with citation bursts.

Main Results:

  • The USA, China, and Germany are leading countries in SCZ and inflammation research.
  • Key journals and frequently used keywords including 'bipolar disorder,' 'brain,' and 'meta-analysis' were identified.
  • A comprehensive overview of the research landscape, including collaborations and influential publications, was established.

Conclusions:

  • This bibliometric study provides a foundational understanding of the SCZ and inflammation research field over three decades.
  • It maps the key players, publications, and thematic areas, offering a broad perspective on the research landscape.