Related Experiment Video
Updated: Sep 6, 2025

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues
Mariama Djaló1, Maria J S A Silva1, Hélio Faustino1,2
1Research Institute for Medicines (iMed. ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal. pedrogois@ff.ulisboa.pt.
Abstract:
The site-selective chemical appendage of multiple functionalities on a native peptide backbone is a highly demanding and complex tool of modern chemical biology. Here, novel NHS-activated acrylates were designed to hold various payloads in a single bioconjugation handle that is able to site-selectively and orthogonally target the N-terminal cysteine of peptides.
More Related Videos
07:11Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
08:14Analysis of the Solvent Accessibility of Cysteine Residues on Maize rayado fino virus Virus-like Particles Produced in Nicotiana benthamiana Plants and Cross-linking of Peptides to VLPs
Published on: February 14, 2013