Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Global Positioning System01:30

Introduction to Global Positioning System

132
The Global Positioning System (GPS) revolutionized positioning on Earth, providing precise location data through satellite ranging. The GPS system was developed in 1978 by the U.S. Department of Defense  for military use, and it became available for civilian applications in 1983, transforming fields including navigation, fleet management, and time synchronization for telecommunications systems.GPS consists of satellites in medium Earth orbit, about 20,200 kilometers above the surface,...
132
Field Application of Global Positioning System01:28

Field Application of Global Positioning System

86
The Global Positioning System (GPS) has become an indispensable tool in fieldwork, offering unparalleled precision and efficiency for surveying, navigation, and infrastructure development. By harnessing signals from a constellation of satellites, GPS receivers determine the location of objects with remarkable speed and accuracy, often completing calculations within a second.Advantages of Modern GPS TechnologyContemporary GPS receivers are designed to meet the practical demands of field...
86
Design Example: Identifying the Locations of Monuments in the Field Using Global Positioning System Device01:30

Design Example: Identifying the Locations of Monuments in the Field Using Global Positioning System Device

166
Surveyors use Global Positioning System (GPS) technology to measure the precise location and elevation of points on Earth. In a recent survey, GPS receivers were used to determine the coordinates and elevations of two park monuments. The process involved careful mission planning, data collection, and correction to ensure accuracy. The survey began with mission planning to identify optimal satellite visibility and minimize Position Dilution of Precision (PDOP). A geodetic control point...
166
Introduction to GIS01:28

Introduction to GIS

185
Geographic Information Systems (GIS) are tools for storing, analyzing, and displaying spatial data alongside related attributes. Unlike traditional information systems that address general queries, GIS incorporates spatial components, enabling users to answer "where" and "how far." For example, GIS can process housing data linked to geographic locations like zip codes, allowing insights into population density or housing distribution through thematic maps.GIS integrates technologies such as...
185
Types of Global Positioning System Surveys01:30

Types of Global Positioning System Surveys

115
GPS surveying methods vary in application, accuracy, and data collection techniques, catering to diverse surveying and mapping needs. Static GPS, kinematic GPS, and real-time kinematic (RTK) surveying are widely used. Each technique offers distinct advantages.Static GPS involves placing one receiver at a known reference point and another at the target point. It collects exact positional data by observing multiple satellite ranges over an extended period, achieving centimeter-level accuracy for...
115
Gyroscope01:02

Gyroscope

3.4K
A gyroscope is defined as a spinning disk in which the axis of rotation is free to assume any orientation. When spinning, the orientation of the spin axis is unaffected by the orientation of the body that encloses it. The body or vehicle enclosing the gyroscope can be moved from place to place, while the orientation of the spin axis remains the same. This makes gyroscopes very useful in navigation, especially where magnetic compasses cannot be used, such as in crewed and crewless spacecraft,...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

More gas, fewer brakes: Mitochondria withhold CoQ at the cost of ferroptosis defense.

The Journal of cell biology·2026
Same author

Tipping the balance: NRF2's dual role in ferroptotic fate.

Oncogenesis·2026
Same author

Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis.

Science advances·2026
Same author

Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.

Nature·2026
Same author

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance.

Nature cell biology·2026
Same author

Adrenocortical Mitochondria-Associated Membranes: Isolation, Characterization, and Lipidoproteomic Response to Mitotane.

Journal of the Endocrine Society·2025

Related Experiment Video

Updated: Sep 6, 2025

Author Spotlight: Exploring Breathing Techniques and Digital Solutions for Enhancing Running Performance
06:26

Author Spotlight: Exploring Breathing Techniques and Digital Solutions for Enhancing Running Performance

Published on: September 27, 2024

602

GPX4: old lessons, new features.

Thamara Nishida Xavier da Silva1, José Pedro Friedmann Angeli1, Irina Ingold2

  • 1Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.

Biochemical Society Transactions
|June 27, 2022
PubMed
Summary

Glutathione peroxidase 4 (GPX4) repairs cell membranes and is crucial for survival. Recent research links GPX4 to ferroptosis, a cell death pathway offering new therapeutic targets for cancer and neurodegeneration.

Keywords:
cell deathferroptosisredox biology

More Related Videos

Trajectory Data Analyses for Pedestrian Space-time Activity Study
16:14

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Published on: February 25, 2013

13.7K
gP2S, an Information Management System for CryoEM Experiments
13:01

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

5.5K

Related Experiment Videos

Last Updated: Sep 6, 2025

Author Spotlight: Exploring Breathing Techniques and Digital Solutions for Enhancing Running Performance
06:26

Author Spotlight: Exploring Breathing Techniques and Digital Solutions for Enhancing Running Performance

Published on: September 27, 2024

602
Trajectory Data Analyses for Pedestrian Space-time Activity Study
16:14

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Published on: February 25, 2013

13.7K
gP2S, an Information Management System for CryoEM Experiments
13:01

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

5.5K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Glutathione peroxidase 4 (GPX4) is a selenocysteine-containing enzyme vital for repairing peroxidised phospholipids.
  • GPX4 plays a critical role in maintaining organismal homeostasis, cell survival, and mammalian embryonic development.

Purpose of the Study:

  • To provide an overview of GPX4 biology for researchers new to the field.
  • To cover recent discoveries concerning GPX4 and its role in cell death pathways.

Main Methods:

  • Literature review of GPX4 biology.
  • Analysis of recent research on ferroptosis and GPX4 dependency.

Main Results:

  • GPX4 is essential for preventing lipid peroxidation.
  • GPX4 is a key regulator of ferroptosis, a distinct form of regulated cell death.
  • Ferroptosis is implicated in diseases such as cancer and neurodegeneration.

Conclusions:

  • Understanding GPX4's role in ferroptosis is crucial for developing new therapeutic strategies.
  • GPX4 is a promising target for treating currently incurable diseases.