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Selectins

Selectins

Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...

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Related Experiment Video

Updated: Sep 6, 2025

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Selepressin in Septic Shock.

Elio Antonucci¹, Manuela Giovini¹, Sara Agosta¹

¹Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.

Shock (Augusta, Ga.)

|June 27, 2022

Summary

This summary is machine-generated.

Norepinephrine is the standard vasopressor for septic shock, but high doses increase mortality. Selepressin, a vasopressin V1A receptor agonist, may reduce norepinephrine needs and adverse effects, warranting further clinical investigation.

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Last Updated: Sep 6, 2025

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Published on: May 7, 2011

Area of Science:

Critical Care Medicine
Pharmacology
Nephrology

Background:

Sepsis and septic shock are associated with high mortality and intensive care unit admissions.
Norepinephrine (NE) is the primary vasopressor after fluid resuscitation for septic shock.
High doses of NE can lead to adverse effects and increased mortality.

Purpose of the Study:

To review the current literature on non-adrenergic vasopressors (NAV), specifically selepressin, in managing septic shock.
To analyze the pathophysiological rationale for using NAV and selepressin.
To differentiate findings from animal and human studies regarding selepressin's efficacy.

Main Methods:

Literature review of studies on septic shock, vasopressors, and selepressin.
Analysis of pathophysiological mechanisms of vasopressor action.
Comparison of data from preclinical (animal) and clinical (human) research.

Main Results:

Selepressin, a selective vasopressin V1A receptor agonist, shows potential to decrease NE requirements.
Selepressin may mitigate adverse effects associated with high-dose catecholamine therapy.
Limited clinical data currently support selepressin use in septic shock.

Conclusions:

Further research is needed to establish selepressin's role in septic shock management.
Future trials should explore early, multimodal interventions targeting both alpha and V1A receptor pathways.
Optimizing vasopressor strategies may improve outcomes in critically ill septic patients.