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Related Concept Videos

Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

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Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
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Structural Protein Function01:56

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
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Fibril-associated Collagen01:11

Fibril-associated Collagen

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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Cytoskeletal Linker Proteins - Plakins01:09

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Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
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Cytoskeletal Accessory Proteins01:13

Cytoskeletal Accessory Proteins

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The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
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Role of Septins01:02

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Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
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Related Experiment Video

Updated: Sep 6, 2025

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
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Fibronectin isoforms in skeletal development and associated disorders.

Neha E H Dinesh1, Philippe M Campeau2, Dieter P Reinhardt1,3

  • 1Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.

American Journal of Physiology. Cell Physiology
|June 27, 2022
PubMed
Summary

Fibronectin, a key extracellular matrix protein, is vital for vertebrate development. Its isoforms play crucial roles in skeletal development, and mutations cause rare skeletal dysplasias.

Keywords:
chondrogenesisextracellular matrixfibronectinmesenchymal stem cellsskeletal dysplasia

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Area of Science:

  • Biochemistry
  • Developmental Biology
  • Cell Biology

Background:

  • The extracellular matrix (ECM) is crucial for cell function, differentiation, and survival.
  • Fibronectin (FN), a major ECM glycoprotein, significantly influences cell fate and vertebrate development.
  • FN expression patterns during stem cell differentiation create a unique stem cell niche.

Purpose of the Study:

  • To review the role of fibronectin isoforms in cartilage and bone physiology and related pathologies.
  • To understand FN's regulatory mechanisms in cellular differentiation during skeletal development.
  • To explore the clinical relevance of matrix-mediated pathways in skeletal disorders.

Main Methods:

  • Literature review focusing on fibronectin's role in skeletal development.
  • Analysis of fibronectin isoforms in cartilage and bone.
  • Examination of mutations in fibronectin and their pathological consequences.

Main Results:

  • Fibronectin isoforms are critical for normal skeletal development.
  • Mutations in fibronectin are linked to rare skeletal dysplasias, including spondylometaphyseal dysplasia.
  • Altered fibronectin function impacts cartilage and bone physiology.

Conclusions:

  • Fibronectin isoforms are essential regulators of skeletal development and homeostasis.
  • Understanding fibronectin's role offers insights into skeletal pathologies and potential therapeutic strategies.
  • Further research into matrix-mediated pathways is crucial for clinical applications.