Cost-Effectiveness Analysis: Personal Systems Approach in Improving Medication Adherence in Adult Kidney Transplant...

Area of Science:

• Transplantation Medicine
• Health Services Research
• Quality Improvement

Background:

• Medication nonadherence is a significant challenge in transplantation.
• Recent interventions focus on person-level strategies linking adherence to daily routines and social support.
• Previous strategies often focused on patient motivation and intention.

Purpose of the Study:

• To evaluate the implementation costs of a person-level intervention designed to improve medication adherence.
• To determine the cost-effectiveness of this intervention in adult kidney transplant recipients.
• To assess the intervention's impact on medication adherence rates.

Main Methods:

• A direct measure microcosting approach was used to estimate intervention costs.
• Key informant interviews and review of implementation expenditures informed cost analysis.
• Cost-effectiveness was calculated by comparing implementation costs, healthcare costs, and adherence improvements.

Main Results:

• The intervention demonstrated a low implementation cost of approximately $520 per patient.
• Significant improvements in medication adherence were observed in patients receiving the intervention.
• Expected healthcare savings associated with improved adherence outweighed the implementation costs.

Conclusions:

• The person-level intervention is a low-cost and effective strategy for enhancing medication adherence.
• This approach offers significant statistical and clinical benefits for adult kidney transplant recipients.
• The intervention presents a promising model for improving long-term transplant outcomes through enhanced adherence.