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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

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[Clinical characteristics related to mortality by COVID-19 in intensive care]

Josué Israel López-Valdés1, Rubén Alejandro Ponce-Mendoza1, Miguel Solís-Barraza2

  • 1Instituto Mexicano del Seguro Social, Hospital General Regional No. 66, Unidad de Cuidados Intensivos. Ciudad Juárez, Chihuahua, México.

Revista Medica Del Instituto Mexicano Del Seguro Social
|June 27, 2022
PubMed
Abstract

Insights

Older age, longer symptom duration, and lower oxygen saturation are key predictors of COVID-19 mortality in intensive care units (ICUs). Cardiovascular and renal complications, along with hyperglycemia, also significantly impact patient outcomes.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • The COVID-19 pandemic necessitated widespread hospital restructuring in Mexico.
  • There was limited information regarding COVID-19 patient development in second-level intensive care units (ICUs).

Purpose of the Study:

  • To identify clinical characteristics associated with COVID-19 mortality in a second-level ICU.
  • To analyze risk factors contributing to death in critically ill COVID-19 patients.

Main Methods:

  • An observational, retrospective cohort study was conducted from March to November 2020.
  • Data included demographics, medical history, clinical, ventilatory, and laboratory characteristics, and complications.
  • Cox regression analysis was used to determine significant risk factors for mortality.

Main Results:

  • In-hospital mortality was 55% among the studied ICU patients.
  • Older age, higher APACHE II scores, longer onset-to-ICU time, and lower oxygen saturation were significantly associated with mortality.
  • The average ICU stay was 8 days.

Conclusions:

  • Pre-admission factors for mortality risk include advanced age, delayed symptom-to-hospital admission, and low oxygenation.
  • In-hospital determinants of mortality involve cardiovascular complications, renal complications, and hyperglycemia.
Keywords:
Coronavirus InfectionsCritical CareRespiration, ArtificialRespiratory Distress Syndrome

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