Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sample size and power for pair-matched case-control studies.

J E Connett, J A Smith, R B McHugh

    Statistics in Medicine
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Free radical generation in hydroperoxide-treated erythrocytes monitored continuously by luminol-amplified chemiluminescence.

    Biochemistry international·1992
    Same author

    The presence of high-titer HLA antibodies in cardiac transplant recipients.

    Transplantation·1992
    Same author

    Role of guinea pig and rabbit hepatic aldehyde oxidase in oxidative in vitro metabolism of cinchona antimalarials.

    Drug metabolism and disposition: the biological fate of chemicals·1992
    Same author

    Comparison of intravenous contrast agents for CT studies in children.

    Acta radiologica (Stockholm, Sweden : 1987)·1992
    Same author

    kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures.

    Molecular pharmacology·1992
    Same author

    Mechanical circulatory support: a necessary adjunct to a cardiac transplantation service.

    Transplantation proceedings·1992
    Same journal

    Optimal Weighted Tests for Replication Studies and the 'Two-Trials Rule' With Multiple Hypotheses.

    Statistics in medicine·2026
    Same journal

    Identifiable Copula-Double-Cox Models: A Fully Parametric Framework for Dependent Right-Censored Survival Data.

    Statistics in medicine·2026
    Same journal

    Moving From Individualized Risk-Based Prevention to Benefit-Based Prevention: Estimating Individualized Life-Years Gained From Prevention Services as a Basis for Eligibility.

    Statistics in medicine·2026
    Same journal

    A Mixture of Distributed Lag Non-Linear Models to Account for Spatially Heterogeneous Exposure-Lag-Response Associations.

    Statistics in medicine·2026
    Same journal

    Practical Considerations for Gaussian Process Modeling for Causal Inference in Quasi-Experimental Studies With Panel Data.

    Statistics in medicine·2026
    Same journal

    Covariate Adjustment for Wilcoxon Two Sample Statistic and Test.

    Statistics in medicine·2026
    See all related articles

    A new formula for sample size in matched-pair case-control studies was developed using an unconditional approach. This method offers an alternative to existing conditional approaches for sample size and power calculations.

    Area of Science:

    • Biostatistics
    • Epidemiology
    • Clinical Trials

    Background:

    • Matched-pair case-control studies are common in epidemiology.
    • Accurate sample size determination is crucial for study power and validity.
    • Existing methods, such as Schlesselman's conditional approach, have limitations.

    Purpose of the Study:

    • To derive a new sample size formula for matched-pair case-control studies.
    • To present an unconditional approach for sample size and power calculations.
    • To compare the proposed method with existing conditional approaches.

    Main Methods:

    • Derivation of a novel sample size formula.
    • Utilizing an unconditional approach based on McNemar's statistic.
    • Numerical comparison via a Monte Carlo simulation study.

    Related Experiment Videos

    Main Results:

    • A new, unconditional sample size formula was successfully derived.
    • The Monte Carlo study provided numerical comparisons between the new and conditional methods.
    • The results highlight differences in sample size and power estimations.

    Conclusions:

    • The derived unconditional formula offers a new tool for sample size calculations in matched-pair studies.
    • This method provides an alternative perspective to traditional conditional approaches.
    • Further research can explore the practical implications and applications of this new formula.