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Related Experiment Video

Updated: Sep 6, 2025

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
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'What puts the 'Hic' into Hiccups?'

Ali Seifi1, Mark R Fox2,3

  • 1Department of Neurosurgery, Division of Neuro Critical Care, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

BMJ Open Gastroenterology
|June 27, 2022
PubMed
Summary

Recurrent hiccups disrupt daily life. A novel suction and swallow tool effectively stopped hiccups in 90% of cases by influencing the aerodigestive tract, offering a new treatment for this common condition.

Keywords:
functional bowel disordergastroesophageal reflux diseaseneurogastroenterology

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Area of Science:

  • Gastroenterology
  • Neurology
  • Otolaryngology

Background:

  • Recurrent hiccups significantly impair quality of life, affecting eating, social interactions, and work.
  • The exact pathophysiology of hiccups and the mechanisms of common remedies remain poorly understood.
  • There is no consensus on whether the hiccup sound originates from glottic or epiglottic closure.

Purpose of the Study:

  • To investigate the pathophysiology of hiccups.
  • To determine the mechanism of action for a novel treatment tool.
  • To gain insight into the cause and treatment of recurrent hiccups.

Main Methods:

  • Video fluoroscopy of the aerodigestive tract during hiccups.
  • Concurrent audio recordings to analyze the 'hic' sound.
  • Utilized a forced inspiratory suction and swallow tool with significant suction pressure (-100 mm Hg).

Main Results:

  • Hiccups were initiated by drinking carbonated soda.
  • The suction and swallow tool successfully terminated hiccups in the patient.
  • The device demonstrated a 90% efficacy rate in terminating hiccups.

Conclusions:

  • The study provides insights into the potential mechanisms behind hiccups.
  • A novel suction and swallow tool offers a highly effective treatment for recurrent hiccups.
  • Further research is warranted to fully elucidate hiccup pathophysiology and optimize treatment strategies.