[Long-term results using a nonionic contrast medium--a report of clinical experiences]

Between January 1982 and May 1986 more than 50,000 patients were examined radiologically with water-soluble (ionic and nonionic) contrast media at the Department of Radiology Rudolfsstiftung, Vienna. In 1983 only 2.2% of the contrast agents used were nonionic, in 1985 the share had increased to 53.3%. During this period the rate of drug-related side effects (DRSE) decreased from 6.9% (1983) to 3.3% (1985). From 1983 to 1985 DRSE were observed with 1952 patients after administration of ionic agents, whereas after application of nonionic media adverse reactions occurred in only 6 cases, so that DRSE rates of 6.98% respectively 0.07% resulted for ionic respectively nonionic contrast media. These results are discussed with regard to the physicochemical properties und physiological actions of ionic and nonionic contrast agents.