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Decrease of Membrane B7-H5 on CD14+ Cells in Severe Acute Pancreatitis Is Related to RANSON Scores and APACHE II
Ruoxin Xu1, Siming Xie1, Ju Gong2
1Department of Critical Care Medicine, The First Affiliated Hospital of Suzhou University, No.188 Shizi Street, Suzhou, 215000, Jiangsu, China.
B7-H5 levels change in severe acute pancreatitis (SAP). Decreased membrane B7-H5 (mB7-H5) on immune cells correlates with SAP severity and may indicate a poor prognosis.
Area of Science:
- Immunology
- Biochemistry
Background:
- B7-H5 is a key immune response ligand.
- Its role as an early indicator in acute pancreatitis (AP) is not well understood.
Purpose of the Study:
- To investigate the role of B7-H5 in severe acute pancreatitis (SAP).
Main Methods:
- Measured soluble B7-H5 (sB7-H5) in plasma and membrane B7-H5 (mB7-H5) on CD14+ cells in SAP patients and healthy donors.
- Stimulated peripheral blood mononuclear cells (PBMCs) with SAP patient serum, LPS, TNF-α, or IFN-γ to assess B7-H5 expression changes.
- Correlated mB7-H5 levels with clinical features of SAP patients.
Main Results:
- SAP patients showed increased sB7-H5 and decreased mB7-H5 on CD14+ cells.
- SAP patient serum, LPS, TNF-α, or IFN-γ induced similar B7-H5 expression changes in vitro.
- Decreased mB7-H5 levels correlated negatively with hematocrit, urea nitrogen, creatinine, lactic acid, RANSON, and APACHE II scores.
Conclusions:
- Altered B7-H5 expression patterns are implicated in the immune response during SAP.
- A decrease in mB7-H5 due to innate immune activation may be linked to a poorer prognosis in SAP patients.
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Assessment:

