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Updated: Sep 6, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Exponential growth of systematic reviews assessing artificial intelligence studies in medicine: challenges and
Thilo von Groote1, Narges Ghoreishi2, Maria Björklund3
1Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany. thilo.vongroote@ukmuenster.de.
Abstract:
The evidence-based medicine (EBM) movement is stepping up its efforts to assess medical artificial intelligence (AI) and data science studies. Since 2017, there has been a marked increase in the number of published systematic reviews that assess medical AI studies. Increasingly, data from observational studies are used in systematic reviews of medical AI studies. Assessment of risk of bias is especially important in medical AI studies to detect possible "AI bias".
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