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Related Experiment Videos

Chelatable lead versus lead in human trabecular and compact bone.

A Schütz, S Skerfving, J O Christoffersson

    The Science of the Total Environment
    |March 1, 1987
    PubMed
    Summary

    Chelation tests for lead exposure can be shortened, as a few hours of urine collection correlates with 24-hour excretion. This method measures recent lead exposure, not long-term accumulation in compact bone.

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    An experimental study on the influence of trace impurities on ionization of atmospheric noble gas dielectric barrier discharges.

    The Analyst·2016

    Area of Science:

    • Environmental Health
    • Toxicology
    • Occupational Medicine

    Background:

    • Lead exposure remains a significant public health concern, particularly for lead workers.
    • Assessing lead body burden and exposure duration is crucial for effective health management.
    • Chelation tests are used to evaluate mobilizable lead, but optimal collection times are debated.

    Purpose of the Study:

    • To determine the correlation between short-term and 24-hour urinary lead excretion after penicillamine chelation.
    • To investigate the relationship between chelatable lead and lead levels in blood and different bone compartments.
    • To assess the utility of chelatable lead as an indicator of long-term lead exposure.

    Main Methods:

    • Active and retired lead workers underwent a single oral dose of 0.5 g penicillamine.

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  • Urinary lead excretion was measured over 6 hours and 24 hours post-dose.
  • Lead levels were analyzed in blood, trabecular bone (vertebrae), and compact bone (finger-bone via X-ray fluorescence).

    • Main Results:

    • A close correlation was observed between 6-hour and 24-hour urinary lead excretion.
    • Chelatable lead showed a strong correlation with blood-lead levels and trabecular bone lead.
    • No association was found between chelatable lead and lead levels in compact bone.

    Conclusions:

    • Shortened urine collection periods (e.g., 6 hours) are sufficient for chelation testing in lead workers.
    • Chelatable lead primarily reflects lead in soft tissues and rapidly turning over trabecular bone.
    • Chelatable lead is not a reliable biomarker for assessing long-term lead exposure stored in compact bone.