Collagen Stimulators in Body Applications: A Review Focused on Poly-L-Lactic Acid (PLLA)

Area of Science:

• Aesthetic medicine and dermatology.
• Regenerative medicine and biomaterials.

Background:

• Growing demand for non-surgical aesthetic procedures for body rejuvenation.
• Soft-tissue dermal fillers, particularly collagen stimulators, are gaining popularity for their efficacy and safety.
• Previous success in facial applications has led to exploring body area treatments.

Purpose of the Study:

• To review the current applications of poly-L-lactic acid (PLLA) for body rejuvenation.
• To summarize published data on PLLA's use in various body areas.
• To provide an overview of injection techniques and aesthetic outcomes for body contouring.

Main Methods:

• Literature review of published data on PLLA for off-facial applications.
• Analysis of studies focusing on specific body areas: neck, chest, buttocks, abdomen, upper arms, thighs, knees, and hands.
• Evaluation of clinical signs, injection modalities, and aesthetic results.

Main Results:

• PLLA is effective for addressing volume loss, skin laxity, cellulite, striae distensae, and wrinkles in body areas.
• Published data, though limited, indicate positive outcomes and patient satisfaction.
• Minor adverse events are typically reported, suggesting a favorable safety profile.

Conclusions:

• Poly-L-lactic acid (PLLA) based collagen stimulators are a viable option for minimally invasive body rejuvenation.
• Further research is needed to optimize treatment protocols and ensure long-term safety and efficacy.
• The use of PLLA and similar collagen stimulators is expanding in clinical practice for diverse body contouring needs.