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B-cell lymphoma-associated hemophagocytic lymphohistiocytosis: A case report
Ademola S Ojo1, Joseph Asemota1, Somtochukwu Ojukwu1
1Department of Internal Medicine, Howard University Hospital, Washington, DC 20060, USA.
Abstract:
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition characterized by an exaggerated but dysregulated immune response resulting in hyperinflammation, with a potential for progression to multiple organ dysfunction and failure. Infectious diseases, inflammatory disorders, malignancies and immunodeficiency syndromes are known triggers of HLH in adults. The present study reported the case of a middle-aged man with HLH triggered by B-cell lymphoma who was successfully treated with dexamethasone; etoposide, prednisone, vincristine, cyclophosphamide, hydroxy-doxorubicin and rituximab chemotherapy; and multiple intrathecal methotrexate with a good outcome.
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