Related Experiment Video

Updated: Jul 18, 2026

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans
04:48

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans

Published on: March 24, 2022

3.3K

Photodynamic Therapy for the Treatment of Fungal Infections

Xuelin Wu1,2, Yongxuan Hu1,2

  • 1Department of Dermatology and Venereology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, People's Republic of China.

Infection and Drug Resistance
|June 28, 2022
PubMed

Insights

Photodynamic therapy (PDT) shows promise as a safe and effective alternative to conventional antifungal drugs for treating fungal infections. This review explores PDT

Area of Science:

  • Dermatology and Mycology
  • Photomedicine

Background:

  • Cutaneous fungal infections cause significant patient distress.
  • Antifungal drug resistance is a growing concern.
  • Safer, effective alternatives are needed.

Purpose of the Study:

  • To review photodynamic therapy (PDT) for fungal infections.
  • Discuss mechanisms, progress, and limitations of PDT.
  • Evaluate PDT as an alternative to conventional antifungals.

Main Methods:

  • Literature review of studies on photodynamic therapy (PDT) for fungal infections.
  • Analysis of PDT mechanisms, efficacy, and safety.
  • Discussion of current research and clinical applications.

Main Results:

  • Photodynamic therapy (PDT) demonstrates effectiveness against fungal infections.
  • PDT exhibits a favorable safety profile with minimal adverse effects.
  • Emerging evidence supports PDT as a viable treatment option.

Conclusions:

  • Photodynamic therapy (PDT) presents a promising alternative for managing fungal infections.
  • Further research is warranted to optimize PDT protocols.
  • PDT offers a potentially safer and more cost-effective treatment strategy.
Keywords:
fungal infectionphotodynamic therapyreview

More Related Videos

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.1K
LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation05:13

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation

Published on: January 24, 2025

450

Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...