Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...

Our everyday observation tells us that all objects close to the Earth naturally tend to fall to the ground. Early philosophers assumed that this downward force was unique to Earth. By the 16th century, Nicolaus Copernicus (1473-1543) put forward the heliocentric theory, which suggested that Earth and other planets orbited the sun, while the Moon orbited the Earth. However, it was Isaac Newton (1642-1727) who linked these two motions together in the 17th century. He reasoned that the force of...

Sir Isaac Newton established the universality of the law of gravitational attraction based on empirical evidence and inductive reasoning. He published his work in Philosophiae Naturalis Principia Mathematica ("the Principia") on July 5, 1687.
Newton's law of gravitational attraction is a fundamental law of physics that governs the attraction between objects. It states that the magnitude of the gravitational force between any two objects is proportional to their masses and inversely...

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...

Norton's theorem is a fundamental principle stating that a linear two-terminal circuit can be substituted with an equivalent circuit, which comprises a current source (ⅠN) in parallel with a resistor (RN). Here, ⅠN represents the short-circuit current flowing through the terminals, and RN stands for the input or equivalent resistance at the terminals when all independent sources are deactivated. This implies that the circuit illustrated in Figure (a) can be exchanged with the...

Elisabeth Kübler-Ross significantly advanced psychology's understanding of the process of dying with her influential book, On Death and Dying (1969). She focused on studying terminally ill individuals and outlined five stages commonly experienced when coping with death: denial, anger, bargaining, depression, and acceptance.
In denial, individuals reject the reality of their condition, often thinking, "This isn't true; I feel fine," as a way to protect themselves from...