Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report
Xin He1, Jian-Ping Ning2, Hui Xu2
1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China.
Abstract:
Renal amyloidosis secondary to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is extremely rare. Here, we reported a 77-year-old woman with ANCA-associated vasculitis. Renal biopsy with Masson trichrome staining showed pauci-immune crescentic glomerulonephritis, and electron microscopy showed amyloid deposition in the mesangial area. Immunofluorescence revealed kappa light chain and lambda light chain negative. Bone marrow biopsy revealed no clonal plasma cell. Finally, she was diagnosed as ANCA-associated vasculitis with secondary renal amyloid A amyloidosis.
