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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Association of ambulatory blood pressure with aortic valve and coronary artery calcification

Yuichi Sawayama1, Takashi Hisamatsu2,3, Aya Kadota2,4

  • 1Department of Cardiovascular Medicine.

Journal of Hypertension
|June 28, 2022
PubMed

Insights

Ambulatory blood pressure (BP) monitoring reveals associations with aortic valve calcification (AVC) and coronary artery calcification (CAC). These findings suggest BP variability, not just average levels, impacts subclinical atherosclerosis.

Area of Science:

  • Cardiovascular Medicine
  • Radiology
  • Hypertension Research

Background:

  • Subclinical atherosclerotic diseases like aortic valve calcification (AVC) and coronary artery calcification (CAC) are significant indicators of cardiovascular risk.
  • Understanding the relationship between blood pressure (BP) patterns and these calcifications is crucial for early detection and prevention.

Purpose of the Study:

  • To investigate the impact of ambulatory blood pressure (BP) monitoring, including mean levels and variability, on the presence of aortic valve calcification (AVC) and coronary artery calcification (CAC).

Main Methods:

  • A population-based, cross-sectional study involving 483 participants (mean age 66.8 years).
  • Assessed office BP, mean ambulatory BP (24-h, awake, asleep), and BP variability (coefficient of variation).
  • Quantified AVC and CAC using computed tomography (Agatston score) and analyzed associations using multivariate-adjusted Poisson regression.

Main Results:

  • AVC was associated with office systolic BP, awake diastolic BP variability, and asleep systolic BP variability.
  • CAC showed associations with office systolic BP, mean 24-h, awake, and asleep systolic BP, as well as asleep systolic BP variability.
  • Prevalence of AVC was 31.9% and CAC was 64.2% in the study cohort.

Conclusions:

  • Ambulatory BP indices, including variability, are associated with both AVC and CAC.
  • Different BP parameters demonstrate distinct associations with the presence of AVC and CAC, underscoring the complexity of BP's role in atherosclerosis.
Abstract

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