Related Experiment Video
Updated: Sep 6, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
Concerted actions of PRR- and NLR-mediated immunity
Jack Rhodes1, Cyril Zipfel1,2, Jonathan D G Jones1
1The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich NR4 7UH, United Kingdom.
Abstract:
Plants utilise cell-surface immune receptors (functioning as pattern recognition receptors, PRRs) and intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) to detect pathogens. Perception of pathogens by these receptors activates immune signalling and resistance to infections. PRR- and NLR-mediated immunity have primarily been considered parallel processes contributing to disease resistance. Recent studies suggest that these two pathways are interdependent and converge at multiple nodes. This review summarises and provides a perspective on these convergent points.
Related Concept Videos
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Regulation of the Unfolded Protein Response
Immune Surveillance by NK Cells and Phagocytes
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Regulation of Nuclear Protein Sorting
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

