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A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

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[Sustained virologic response in patients with hepatitis C and chronic kidney disease]

Erick Augusto Jasso-Baltazar1, Francisco Alfonso Solís-Galindo2, Melisa Alejandra Muñoz-Hernández3

  • 1Instituto Mexicano del Seguro Social, Hospital de Especialidades No. 71, Servicio de Medicina Interna. Torreón, Coahuila, México.

Revista Medica Del Instituto Mexicano Del Seguro Social
|June 28, 2022
PubMed

Insights

Hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) in Mexican patients with chronic kidney disease (CKD) on hemodialysis achieved a 100% sustained viral response. This HCV treatment demonstrated mild adverse effects, indicating its safety and efficacy in this population.

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • Patients with chronic kidney disease (CKD) exhibit a higher prevalence of hepatitis C virus (HCV) infection.
  • Untreated HCV infection significantly increases morbidity and mortality in CKD patients.
  • Direct-acting antiviral (DAA) therapies are available in Mexico, but their efficacy and safety in CKD patients undergoing hemodialysis remain understudied.

Purpose of the Study:

  • To evaluate the efficacy, measured by sustained viral response (SVR), of DAAs in Mexican patients with CKD on hemodialysis and chronic HCV infection.
  • To assess the safety profile of DAAs in this specific patient cohort.

Main Methods:

  • A real-life cohort study was conducted, including patients with CKD on hemodialysis and HCV infection treated with DAAs.
  • Descriptive statistics were used to analyze patient clinical characteristics.
  • Efficacy was determined by achieving SVR, and safety was assessed by the frequency of treatment-associated adverse effects.

Main Results:

  • The study included 25 patients with a mean age of 57.8 years and a median of 5 years on hemodialysis.
  • All patients received 8 weeks of glecaprevir/pibrentasvir treatment, with 96% having HCV genotype 1B.
  • A 100% SVR rate was observed, with headache, nausea, and fatigue being the most common adverse effects.

Conclusions:

  • Direct-acting antiviral treatment with glecaprevir/pibrentasvir achieved a 100% sustained viral response in Mexican patients with HCV and CKD on hemodialysis.
  • The treatment demonstrated a favorable safety profile with mild adverse effects in this population.
  • These findings support the use of DAAs for HCV treatment in patients with advanced kidney disease on hemodialysis in Mexico.
Abstract

Keywords:
Chronic Kidney DiseaseDirect-Acting AntiviralsHepatitis C VirusSustained Virologic Response

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