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COVID-19 and venous thromboembolism risk in patients with sickle cell disease

Ashima Singh1, Amanda M Brandow1, Ted Wun2

  • 1Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI.

Blood Advances
|June 28, 2022
PubMed

Insights

COVID-19 hospitalization did not increase venous thromboembolism (VTE) risk in sickle cell disease (SCD) patients. This study found similar VTE rates in SCD patients hospitalized with or without COVID-19.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Venous thromboembolism (VTE) is a serious risk for sickle cell disease (SCD) patients and those with severe COVID-19.
  • While SCD patients face higher risks for severe COVID-19, the impact of COVID-19 on VTE risk within this group is not fully understood.

Purpose of the Study:

  • To investigate whether COVID-19 infection elevates VTE risk in hospitalized sickle cell disease patients.
  • To compare VTE incidence in SCD patients hospitalized with COVID-19 versus those hospitalized for other conditions.

Main Methods:

  • Utilized TriNetX electronic health record data for hospitalized SCD patients in 2020.
  • Compared VTE rates within six months post-hospitalization between SCD patients with and without COVID-19.
  • Employed adjusted Poisson regression to estimate risk ratios, controlling for baseline characteristics.

Main Results:

  • Among 281 SCD patients hospitalized with COVID-19, 12.46% experienced VTE.
  • Among 4873 SCD patients hospitalized without COVID-19, 8.58% experienced VTE.
  • Adjusted analysis revealed no significant difference in VTE rates between the two groups (aRR: 1.06; 95% CI: 0.79-1.41).

Conclusions:

  • Hospitalization for COVID-19 does not appear to further increase the risk of venous thromboembolism in patients with sickle cell disease.
  • Findings suggest that established VTE risk factors in SCD may outweigh the additional risk from COVID-19 during hospitalization.

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