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Adult Height as a Risk Factor for Developing Colorectal Cancer: A Population-Based Cohort Study in Thailand
Jiranya Bureemas1, Jarin Chindaprasert2, Krittika Suwanrungruang3,4
1Doctor of Philosophy Program in Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Thailand.
Asian Pacific Journal of Cancer Prevention : APJCP
|June 28, 2022
Summary
This study found no statistically significant link between adult height and colorectal cancer (CRC) risk in Thailand. However, a U-shaped trend suggests further investigation in ASEAN populations is warranted.
Area of Science:
- Epidemiology
- Oncology
- Public Health
Background:
- Previous research links taller stature to increased colorectal cancer (CRC) risk, primarily in Western populations.
- Limited and inconsistent data exist for Asian populations, particularly within ASEAN countries.
- This study addresses the gap by examining height and CRC risk in a Thai cohort.
Purpose of the Study:
- To investigate the association between adult height and the risk of developing colorectal cancer (CRC).
- To provide insights relevant to the ASEAN region, characterized by generally shorter statures.
Main Methods:
- A population-based cohort study in Khon Kaen, Thailand, involving 14,418 participants.
- Histological confirmation of 118 colorectal cancer (CRC) cases.
- Cox proportional hazard regression analysis to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
Main Results:
- Over a median of 21.7 years, no statistically significant association was found between height quintiles and CRC risk.
- The highest height quintile showed a hazard ratio of 1.29 (95% CI, 0.76-2.20) compared to the lowest.
- A U-shaped trend was observed, suggesting potential non-linear relationships.
Conclusions:
- Adult height was not a statistically significant predictor of colorectal cancer (CRC) risk in the Thai population.
- The observed trend warrants further investigation in large-scale studies within ASEAN countries.
- Findings highlight the need for context-specific research on height and CRC risk.
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